منابع مشابه
Non-Viral Delivery Systems in Gene Therapy
Recent advances in molecular biology combined with the culmination of the Human Ge‐ nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi‐ fied as targets for therapeutic approaches. In addition, the development of high-throughput screening techniques (e.g., cDNA microarra...
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Modified cyclodextrins as novel non-viral vectors for neuronal siRNA delivery: focus on Huntington’s disease Author(s) Godinho, Bruno M. D. C. Publication date 2014 Original citation Godinho, B. M. D. C. 2014. Modified cyclodextrins as novel non-viral vectors for neuronal siRNA delivery: focus on Huntington’s disease. PhD Thesis, University College Cork. Type of publication Doctoral thesis Righ...
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The ability to mediate targeted and specific delivery of therapeutics to cancer cells remains one of the most important hurdles in effectively treating cancer. This aspect also remains as one of the greatest limitations of gene therapy as well. Targeted vectors based on the use of DNA-binding agents attached to cell specific ligands or "molecular conjugates" were created with the goal of over-c...
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INTRODUCTION:• Gene delivery into joints is considered to become a useful strategy for the treatment of joint diseases. Viral vectors are commonly used because of their high transduction efficacies. Despite of recent improvement of the vectors, the viral vectors are associated with some unsolved problems such as induction of inflammatory responses and undesired generation of replication-compete...
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Gene therapy is often referred to as transfer of transgenes into the somatic cells of a patient to obtain a therapeutic effect .One of the goals for all such therapies is efficient and safe delivery of the desired extrinsic genes into target cells, thereby increasing the therapeutic efficiency (Robson & Hirst, 2003). This has been a major obstacle in gene therapy experiments (Sarbolouki et al.,...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2014
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2013.09.061